Ondansetron Hydrochloride
Ondansetron Hydrochloride is a competitive serotonin 5-HT3 receptor antagonist. It works both peripherally on vagal nerve terminals in the gastrointestinal tract and centrally in the chemoreceptor trigger zone to block the serotonin signals that trigger the vomiting reflex.
Dosage by Body Weight
Dosage varies significantly based on the indication (chemotherapy vs. surgery) and age. Must be taken exactly as prescribed by a physician. Pediatric dosage is typically calculated based on weight or body surface area.
- Body Weight
- Below 5 kg
- Dose
- Not routinely recommended
- Frequency
- Use only if prescribed
- Tracking Notes
- Efficacy and safety in infants weighing under 5 kg or under 6 months of age have not been established.
- Body Weight
- 5-7 kg
- Dose
- 0.75 mg to 1 mg
- Frequency
- Every 8 to 12 hours as needed
- Tracking Notes
- Dosing is typically calculated at approximately 0.15 mg/kg per dose.
- Body Weight
- 8-10 kg
- Dose
- 1.2 mg to 1.5 mg
- Frequency
- Every 8 to 12 hours as needed
- Tracking Notes
- Best administered using a precise oral syringe for liquid formulation.
- Body Weight
- 11-15 kg
- Dose
- 1.6 mg to 2 mg
- Frequency
- Every 8 to 12 hours as needed
- Tracking Notes
- 2 mg corresponds to 2.5 mL of standard 4 mg/5 mL oral solution.
- Body Weight
- 16-20 kg
- Dose
- 2.4 mg to 3 mg
- Frequency
- Every 8 to 12 hours as needed
- Tracking Notes
- Consult a pediatrician to determine if a 4 mg disintegrating tablet is appropriate.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routinely recommended | Use only if prescribed | Efficacy and safety in infants weighing under 5 kg or under 6 months of age have not been established. |
| 5-7 kg | 0.75 mg to 1 mg | Every 8 to 12 hours as needed | Dosing is typically calculated at approximately 0.15 mg/kg per dose. |
| 8-10 kg | 1.2 mg to 1.5 mg | Every 8 to 12 hours as needed | Best administered using a precise oral syringe for liquid formulation. |
| 11-15 kg | 1.6 mg to 2 mg | Every 8 to 12 hours as needed | 2 mg corresponds to 2.5 mL of standard 4 mg/5 mL oral solution. |
| 16-20 kg | 2.4 mg to 3 mg | Every 8 to 12 hours as needed | Consult a pediatrician to determine if a 4 mg disintegrating tablet is appropriate. |
Formulation
Purpose
Prevention and treatment of nausea and vomiting induced by cancer chemotherapy, radiation therapy, and surgery.
Generic Name
Ondansetron HydrochlorideBranded Drug Names
Ondansetron Hydrochloride is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.